Search results for "Ventricular Outflow Obstruction"

showing 3 items of 3 documents

Simulation of left ventricular outflow tract (LVOT) obstruction in transcatheter mitral valve-in-ring replacement.

2020

Left ventricular outflow tract (LVOT) obstruction is a feared complication of transcatheter mitral valve replacement (TMVR). This procedure leads to an elongation of LVOT in the left ventricle (namely, the neoLVOT), ultimately portending hemodynamic impairment and death. This study sought to understand the biomechanical implications of LVOT obstruction in two patients who underwent TMVR as an "off-label" application of the Edwards SAPIEN 3 (S3) Ultra transcatheter heart valve (THV). A computational framework of TMVR was developed to assess the neoLVOT area and quantify the sub-aortic flow structure. We observed that the annuloplasty ring serves as the key anchor zone of S3 Ultra THV. A good…

medicine.medical_specialtyCardiac Catheterizationmedicine.medical_treatment0206 medical engineeringBiomedical EngineeringBiophysicsHemodynamics02 engineering and technologyVentricular Outflow ObstructionFluid-solid interaction03 medical and health sciences0302 clinical medicineInternal medicineMitral valveMedicineVentricular outflow tractHumansFinite-element analysisHeart valveHeart Valve Prosthesis Implantationbusiness.industryMitral valve replacementSettore ING-IND/34 - Bioingegneria Industriale020601 biomedical engineeringmedicine.anatomical_structureTreatment OutcomeVentricleHeart Valve ProsthesisCardiologyMitral ValvebusinessComplicationTranscatheter mitral valve replacement030217 neurology & neurosurgeryEdwards sapienMedical engineeringphysics
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Numerical simulation of transcatheter mitral valve replacement: The dynamic implication of LVOT obstruction in the valve-in-ring case.

2022

Transcatheter mitral valve replacement (TMVR) has been used for “off-label” treatment when annuloplasty band ring for mitral repair fails. However, the complex anatomy and function of the mitral valve may lead to fatal complications as a result of the left ventricular outflow tract (LVOT) obstruction in TMVR. We report the structural and hemodynamic response of LVOT obstruction resulting from TMVR with the Edwards SAPIEN 3 Ultra (S3) device. We modified the original Living Heart Human Model (LHHM) to account for a failed mitral valve with an annuloplasty band ring and simulated the cardiac beating condition in the setting of S3 device implantation. Findings demonstrated a high dynamic behav…

Heart Valve Prosthesis ImplantationHeart Defects CongenitalHistoryCardiac CatheterizationPolymers and PlasticsRehabilitationBiomedical EngineeringBiophysicsMitral Valve InsufficiencyFinite Element (FE) analysisIndustrial and Manufacturing EngineeringVentricular Outflow ObstructionTreatment OutcomeRisk FactorsComputational Fluid Dynamic (CFD)Living heart human modelHeart Valve ProsthesisHumansMitral ValveOrthopedics and Sports MedicineBusiness and International ManagementTranscatheter mitral valve replacementJournal of biomechanics
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Direct measurement of left ventricular outflow tract by transthoracic real-time 3D-echocardiography increases accuracy in assessment of aortic valve …

2007

Evaluation of aortic valve stenosis is a major clinical application of echocardiography. The widely employed continuity equation requires determination of the left ventricular outflow tract (LVOT) area. We aimed at testing whether direct area measurement in a volume data set is superior to conventional calculation from the LVOT diameter.We performed LVOT measurement in 20 normal subjects and 83 patients with moderate to severe aortic stenosis with a transthoracic real-time three-dimensional echocardiography (3D-TTE) technique in two systolic frames. The off-line 3D-evaluation allows full choice of section planes within the acquired volume data set. The aortic valve area was calculated from …

Moderate to severeAortic valveAdultMalemedicine.medical_specialtyEchocardiography Three-DimensionalReal time 3d echocardiographyVentricular Outflow ObstructionYoung AdultInternal medicinemedicineVentricular outflow tractHumansSystoleAgedAged 80 and overbusiness.industryAortic Valve StenosisMiddle Agedmedicine.diseaseStenosismedicine.anatomical_structureAortic valve areaEchocardiographyAortic valve stenosisCardiologyFemaleCardiology and Cardiovascular MedicinebusinessInternational journal of cardiology
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